代表成果

在国内外有影响的学术刊物上发表论文80余篇，先后承担国家自然科学基金，上海市基础研究重点课题，教育部高等学校博士学科点专项科研基金等研究项目，获国家发明专利10项。主要从事药物化学、天然产物全合成和结构改造、抗肿瘤药物开发领域研究，

论文

1. Synthesis and evaluation of alkannin and shikonin oxime derivatives as potent antitumor agent..Wang, R.; Zhang, X.; Song, H.; Zhou, S.; Li, S..Bioorg. Med. Chem. Lett..

2. Inhibitors and Prodrugs Targeting CYP1: A Novel Approach in Cancer Prevention and Therapy..Cui, J.; Li, S..Curr. Med. Chem..

3. Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy..Song, H.; Wang, R.; Zhou, S.; Li, S..ChemMedChem.

4. A Novel and Efficient Total Synthesis of Shikonin..Wang, R.; Guo, H.; Cui J.; Li, S..Tetrahedron Lett.

5. Shikonin and Its Derivatives: A Patent Review..Wang, R.; Yin, R.; Zhou, W.; Xu, D.; Li, S..Expert. Opin. Ther. Pat..

6. An Efficient Multigram Synthesis of Alkannin and Shikonin.Wang, R.; Zhou, S.; Hudagula, J.; Zheng, X.; Zhou, W.; Li, S..Eur. J. Org. Chem..

7. emi-synthesis and Antitumor Activity of 6-isomers of 5, 8-O-dimethyl Acylshikonin Derivatives..hou, W.; Zhang, X.; Xiao, L.; Ding, J.; Liu, Q.; Li, S..Eur. J. Med. Chem..

8. Cancer Therapeutic Agents Targeting Hypoxia- inducible Factor-1..Wang, R.; Zhou, S.; Li, S..Curr. Med. Chem..

9. Synthesis and Antitumour Activity of β-hydroxyiso- valerylshikonin analogues..Rao, Z.; Liu, X.; Zhou, W.; Yi, J.; Li, S..Eur. J. Med. Chem..